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KMID : 0604220070140020045
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Korean Journal Investigative Dermatology
2007 Volume.14 No. 2 p.45 ~ p.50
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Effects of Colostrum on Keratinocyte Differentiation and Wound Healing
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Kwon Yoo-Bin
Lee Jeung-Hoon
Jeon Eun-Kyung
Kim Chang-Duk
Choi Dae-Kyoung
Sohn Kyung-Cheol
Nam Myoung-Soo
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Abstract
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Skin has a role as a protective barrier against environmental insults, such as chemicals, pathogens, and UV light. Much of this protective function is dependent on the epidermis, a multi-layered epithelium that is composed of various cell types, including keratinocytes and melanocytes. Keratinocytes provide the rigid stratified structure through highly complicated and tightly regulated process of differentiation. To investigate the effect of colostrum, we treated primary cultured keratinocytes with colostrum, and performed Western blot analysis against several keratinocyte differentiation markers. Interestingly, colostrum increased the expression of early differentiation markers such as keratin 1, 10 and involucrin. In addition, colostrum also increased the expression of late differentiation markers including loricrin and filaggrin, suggesting that colostrum may have impact on the signal involved in the onset of keratinocyte differentiation. In wound healing test, colostrum did not show dramatic improvement of wound closure. However, colostrum increased the granulation tissue volume in dermis, suggesting that it has beneficial effect on wound healing. Together, these results suggest that colostrum may be applicable for improvement of skin condition in several pathologic status such as atopy.
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KEYWORD
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Colostrum, Keratinocyte Differentiation, Wound Healing
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